Epidural clonidine used as an adjunct to local anesthetics has three diverse mechanisms of action. Initial, the stimulation of alpha-2-receptors in the dorsal horn decreases discomfort transmission. Secondly, clonidine could potentially cause neighborhood vasoconstriction that limits vascular elimination of area epidural anesthetics. Find out the implications for potential wellness https://www.proleviate.com/post/the-new-pain-killer-conolidine