Ising machines are domain-specific computers that solve combinatorial optimization problems (COPs). They utilize an Ising model to represent a COP and search for the optimal spin configuration of the Ising model to solve the COP. Most Ising machines are based on simulated annealing (SA) and update the spin configuration according to single-spin-flip Markov Chain Monte Carlo methods. https://www.truvisionhealthftp.com/