Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals with the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic experiments have recognized recurrent mutations in genes regulating tumor mobile-microenvironment interactions... https://elizabethp530kqz7.wikissl.com/user